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KMID : 1094720210260020201
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Biotechnology and Bioprocess Engineering
2021 Volume.26 No. 2 p.201 ~ p.207
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Evaluation of Mechanical and Thermal Properties of Hydroxyapatite-levan Composite Bone Graft
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Song Young-Hoon
Joo Kye-Il
Seo Jeong-Hyun
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Abstract
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Biodegradable materials have been received great attention as bone graft substitutes for bone regeneration and tissue engineering. However, their low mechanical property remains a major challenge for the use in load-bearing applications. Here, we developed mechanically reinforced composite scaffold containing adhesive levan as a binder for sintered hydroxyapatite (sHAp) and then examined the mechanical and thermal properties of the composite scaffold. We found that sHAp-levan composite scaffold exhibited remarkably enhanced mechanical strength, which is similar to that of polymethyl methacrylate (PMMA) bone cement. This composite scaffold can be utilized as a promising bone graft for bone regeneration and tissue engineering.
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KEYWORD
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bone graft, hydroxyapatite, levan, composite scaffold, sintering
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